The Age of Aquaticus

Doctor and special correspondent Avir Mitra takes Executive Editor Soren Wheeler, plus a live studio audience, on a journey from the operating room to inside the body to the farm to the sewers and back again—searching for answers to an alarming threat to humanity’s existence as we know it: antibiotic resistance in bacteria. This live show, performed in New York City and also in Little Rock, Arkansas, is part of a series we’re doing with Avir that we are calling “Viscera.” Each event is a conversation that takes the audience on a journey into a quirk or question or mystery inside of us, and gives them a visceral experience of the viscera within us. The previous installment of the series was called “The Elixir of Life.” (https://radiolab.org/podcast/the-elixir-of-life)Special thanks to all of Little Rock Public Radio (especially Grace Zafasi and Jonathan Seaborn), Thomas Patterson, The Greene Space staff, CALS Ron Robinson Theater, Tom Philpott, Stephen Roach, Kate Shaw, Alex Wong, Maryn McKenna, and Kerri McClimen.If you are a patients or a doctor, and you are interested in phage therapy, please contact [email protected] EPISODE CREDITS: Reported by - Avir MitraProduced by - Jessica YungSound design contributed by - Jeremy Bloom and Jessica YungFact-checking by -Natalie Middleton EPISODE CITATIONS: Videos - Check out the video from the Viscera live show (and a bonus Q&A with Bruce Stewart-Brown and Steffanie Strathdee) on Radiolab’s YouTube (https://zpr.io/3BK9MqJYVKQA). A deep dive (https://zpr.io/WNQNfgiNvKeZ) on bacteriophages with Avir Mitra and Steffanie Strathdee, also on Radiolab’s Youtube.. Books - The Perfect Predator (https://theperfectpredator.com/) by Dr. Steffanie Strathdee’s telling of her battle against a killer superbug. Plucked (https://zpr.io/PudGMEuzgU9X) by Maryn Mckenna a detailed accounting of chicken farming’s practice of using antibiotics. Signup for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing [email protected] support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

A strange brew that's hard to resist, even for a modern day microbe.In the war on devilish microbes, our weapons are starting to fail us. The antibiotics we once wielded like miraculous flaming swords seem more like lukewarm butter knives. But in this episode, originally released in 2015, we follow an odd couple, of a sort, to a storied land of elves and dragons. There, they uncover a 1,000-year-old secret that makes us reconsider our most basic assumptions about human progress and wonder: what if the only way forward is backward? Special thanks to Steve Diggle, Professor Roberta Frank, Alexandra Reider and Justin Park (our Old English readers), Gene Murrow from Gotham Early Music Scene, Marcia Young for her performance on the medieval harp and Collin Monro of Tadcaster and the rest of the Barony of Iron Bog.Can’t get enough of that sweet, sweet antibiotic resistance content? Then you’ll be over the moon about next week’s release. It’s the podcast cut of our most recent installment of our live show series called Viscera. This one features executive editor Soren Wheeler and Avir Mitra, and it’s all about how our millenia's-long war against bacteria came to a tipping point in this modern age.Subscribe or follow our show on your favorite streaming platform and you’ll be the first to know when it drops. EPISODE CREDITS: Reported by - Latif NasserProduced by - Matt Kielty and Soren Wheeler EPISODE CITATIONS:Articles - Uncovering the multifaceted mechanism of action of a historical antimicrobial (https://zpr.io/mucw6Td6LBxT) by Harrison, F et al, 2026 bioRxv (PREPRINT). In this article Freya and her team describe the mechanisms under which Bald’s Remedy actually works. Signup for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing [email protected] support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

If a species is horrible enough, do we have the right to kill it forever? Seventy years ago, a nightmare parasite feasted on the live flesh of warm-blooded creatures in North America: the screwworm. That is, until a young scientist named Edward F. Knipling discovered a crucial screwworm weakness and hatched a sweeping project to wipe them out. Knipling’s seemingly zany plan to spray screwworms out of planes all over the continent— with US taxpayer money— succeeded, becoming one of humanity’s biggest environmental interventions ever. Today, screwworms have been gone so long that none of us in North America even remember them. But now, they’re coming back. And they’re forcing us to ask: in an era of climate change and rapid mass extinction— should we kill off a species on purpose? Special thanks to James P. Collins, Max Scott, Amy Murillo, Daniel Griffin, Phil Kaufman, Katie Barnhill, Arthur Caplan, Ron Sandler, Yasha Rohwer, Aaron Keefe, Gwendolyn Bogard, Maria Sabate, Meredith Asbury, and Joanne Padrón Carney

In this episode, we consider a creature we often don’t think much about—the snail. And not just snails, but their sex lives. Which, as it turns out, is epic. There is persuasion and subterfuge, spaghetti penises and co-copulation. And this very surprising habit—erm kink—of making tiny arrows (actually!) and stabbing each other with them. Known as a “love dart,” these limestone daggers aren’t just a strange trick of nature—they have a deep evolutionary purpose. Special thanks to Menno Schilthuizen and Aaron Chase.EPISODE CREDITS: Hosted by - Molly WebsterReported by - Molly WebsterProduced by - Mona Madgavkar, Annie McEwen, Molly WebsterSound design contributed by - Mona Madgavkar, Annie McEwenFact-checking by - Diane A. Kellyand Edited by  - Alex Neason EPISODE CITATIONS:Videos -  A love dart being DARTED! (https://zpr.io/rYhLwXhaxQQP)  – Molly has watched this video so many timesArticles - Changes in the reproductive system of the snail Helix aspersa caused by mucus from the love dart. (https://zpr.io/xxjuCcTyiVJV) by Koene JM, Chase R. J Exp Biol. The snail's love-dart delivers mucus to increase paternity. By Chase R, Blanchard KC. Proc Biol Sci. A love-dart at the heart of sexual conflict in snails (https://zpr.io/X2ANHPaEg5sr)  by Foote C ** This article has an image of eight different love darts, and it’s what Molly shows to Soren in the episode (this image is one of her favorite research finds!)  Books - “Nature’s Nether Regions: What the Sex Lives of Bugs, Birds, and Beasts Tell Us About Evolution, Biodiversity, and Ourselves” (https://zpr.io/ktMvJbZciCdD)  by evolutionary biologist Menno Schilthuizen. Signup for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing [email protected]. Leadership support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

In this episode, first aired in 2014, we examine three very different kinds of black boxes—spaces where we know what’s going in, we know what’s coming out, but can’t see what happens in-between. From the darkest parts of metamorphosis to a sixty-year-old secret among magicians, and the nature of consciousness itself, we shine some light on three questions. But for each, we contend with an answerless space, leaving just enough room for the mystery and magic, always wondering what’s inside the Black Box. EPISODE CREDITS: Reported by Tim Howard and Molly WebsterProduced by Tim Howard and Molly Webster EPISODE CITATIONS:Radio Show: ABC's Keep Them Guessing (https://tinyurl.com/9r9zmftr)LATERAL CUTS:Last year we shared a story on our feed about butterfly researcher Dr. Martha Weiss, and how she befriended a little boy on the other side of the world who wanted to do his own caterpillar memory study. Martha’s daughter Annie Rosenthal captured the whole adventure on tape and produced a gorgeous audio feature, “Caterpillar Roadshow,” which was first published in the audio magazine Signal Hill. You can find it on our feed (https://zpr.io/xPdAYXFUMr4s)–or on Signal Hill’s website. (https://zpr.io/a4bjPKeXJQWK) Signup for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing [email protected]. Leadership support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.