Huberman Lab

In this Huberman Lab Essentials episode, my guest is Dr. Oded Rechavi, a professor at Tel Aviv University who studies genetics, epigenetics and the inheritance of acquired traits. We discuss how DNA, RNA and epigenetic mechanisms determine what information can pass between generations, and why acquired traits are generally not thought to be inherited. We also explain research in C. elegans showing how small RNAs can transmit antiviral resistance and influence behavior across generations, what these findings might mean for mammals and humans, and potential future applications for reproductive health and diagnostics. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps (00:00:00) Oded Rechavi (00:00:24) DNA, Genome, RNA & Proteins (00:03:43) Somatic vs. Germ Cells; Inheritance (00:06:05) Sponsor: Eight Sleep (00:07:23) Lamarck vs. Darwin, Inheritance of Acquired Traits (00:09:45) Weismann Barrier, Epigenetic Reprogramming (00:13:05) RNA & Transgenerational Inheritance (00:13:54) Model Organisms, C. elegans (00:16:59) Inheritance of Acquired Traits in C. elegans (00:17:14) Sponsor: AG1 (00:18:40) RNA Interference, Small RNAs & Gene Silencing (00:22:46) Viral Resistance Across Generations (00:24:53) Small RNAs, Mammals & Inherited Effects (00:26:00) Brain Activity, Memory & Heritable Information (00:28:46) Neuronal Small RNAs & Behavior Across Generations (00:29:59) Germ Cells, Development & Heritable RNA (00:31:29) Sponsor: LMNT (00:33:11) Future Applications, Exercise, IVF & RNA Diagnostics (00:35:16) Acknowledgements Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Jared Rutter, PhD, Professor of Biochemistry at the University of Utah and Howard Hughes Medical Institute Investigator, is a leading expert on mitochondria and metabolism. He explains how mitochondria produce the energy for your cells to work but also how they regulate cell growth and replication and thereby contribute to health and disease. We also discuss how mitochondria are linked to aging, cancer, and other diseases. Our conversation explores your metabolism as the composite of trillions of individual cells and points to new ways to improve health, avoid, and treat diseases. Show notes: https://go.hubermanlab.com/297-jared-rutter Pre-order Protocols: https://protocolsbook.com Thank you to our sponsors AG1: https://drinkag1.com/huberman Joovv: https://joovv.com/huberman BetterHelp: https://betterhelp.com/huberman Eight Sleep: https://eightsleep.com/huberman Function: https://functionhealth.com/huberman Timestamps (00:00:00) Jared Rutter (00:02:29) Metabolism, Cells; Aging (00:08:36) Mitochondria, Origin & Cell Complexity (00:13:07) Sponsors: Joovv & BetterHelp (00:15:16) Mitochondria Genome, Inheritance (00:18:18) Mitochondria & Spatial Distribution; Cell-Specific Metabolism (00:25:59) Nutrient Energy, Hormones, Fat Cells (00:31:13) Glucose, ATP Conversion, Pyruvate (00:36:41) Cell Choice: Energy or Growth, Cancer; Virus (00:46:02) Sponsors: AG1 & Eight Sleep (00:48:36) Microbiome, Role of Humans (00:51:44) Molecule Discovery Process, MPC1, MPC2 (00:59:42) Cell Resource Sensing, Fasting, Glucagon, Fat Cells; Neurons, Heart (01:07:03) Cell Resource Allocation, MPC, Heart Failure; Disease (01:11:46) Sponsor: Function (01:13:24) Cell Size vs Fuel Balance, Cell Identity & Disease (01:20:43) MPC Discovery, Genetics, Model Systems (01:24:29) Lactate, Oxygen, Exercise; Energy Prioritization Hierarchy (01:31:32) Cancer, Mutations, Metabolism Changes & Warburg Effect (01:36:18) Cancer Challenges & Therapies (01:43:00) Therapy Combinations, Unique Cancer Mutations & Metabolism (01:48:31) Technology to Visualize Metabolism; Disease, Metabolism & Scents (01:56:34) Excess Energy & Mitochondria, Reactive Oxygen Species (02:01:12) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

In this Huberman Lab Essentials episode, my guest is Dr. Gina Poe, PhD, a Professor of Integrative Biology and Physiology at the University of California, Los Angeles (UCLA). We discuss the architecture of sleep and how each stage supports distinct functions, including memory consolidation, creativity, brain restoration, and emotional processing. We also explain science-supported tools to improve sleep quality, support cognitive performance, and hormone balance. Show notes: https://go.hubermanlab.com/Y6JKgFE Thank you to our sponsors AG1: https://drinkag1.com/huberman LMNT: https://drinklmnt.com/huberman Eight Sleep: https://eightsleep.com/huberman Timestamps (00:00:00) Gina Poe (00:00:19) Sleep States, Perfect Night's Sleep (00:02:23) Early Sleep, Memory Processing, Dreams (00:04:34) Growth Hormone & Early Sleep, Tool: Consistent Bedtime (00:06:47) Sponsor: LMNT (00:08:20) Alcohol & Negative Sleep Effects (00:09:18) Middle Sleep States, Creativity (00:10:32) Waking During Night, Nighttime Urination (00:11:39) Later Sleep, REM, Deep Sleep; Sleepwalking (00:14:01) Morning Grogginess; Sleep Trackers (00:15:53) Early Sleep "Washout", Brain Waste Clearance (00:19:56) Sponsor: Eight Sleep (00:21:14) Locus Coeruleus, Learning & REM Sleep, Tool: Calm Bedtime Routine (00:25:16) Sleep Spindles, P Waves, Learning & Creativity (00:28:38) Sponsor: AG1 (00:29:56) Trauma Recovery, REM Sleep, Locus Coeruleus (00:33:29) Acknowledgements Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

My guest is Joe Liemandt, technology entrepreneur and principal of Alpha School, a K-12 model that uses AI and individualized learning to help students master academics in just two hours a day, freeing the rest of their time to build businesses, conduct experiments, engage with their communities, and develop practical life skills. We discuss Alpha’s promising results, tools parents and educators can use today, and Joe’s vision for how AI could transform education and human potential. Show notes: https://go.hubermanlab.com/296-joe-liemandt Pre-order Protocols: https://protocolsbook.com Huberman Lab live events: https://www.hubermanlab.com/events Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman Lingo: https://hellolingo.com/huberman Helix Sleep: https://helixsleep.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps (00:00:00) Joe Liemandt (00:03:16) History of Traditional Classroom Model; Education Milestones (00:08:08) Sponsors: David & Lingo (00:10:25) Alpha School, High Standards & Support (00:22:33) Effective Support, Academics vs Athletics; Homeschooling (00:30:03) AI, Individualized Learning & Mastery (00:34:31) Teacher Education, Standardized Tests, Role of School (00:40:52) Sponsors: AG1 & Helix Sleep (00:43:42) AI, Scaffolding Learning, Mastery; Working Memory & Fluency (00:52:41) Working Memory, Focus; Gifted Kids (01:00:30) Basics Mastery, Grade Level Catch-Up, Individualized AI Lessons & Pace (01:06:57) Sponsor: LMNT (01:08:17) Shame, Motivation, Growth Rate; Overcoming Mental Blocks & Paying Kids (01:20:55) Suffering & Motivation, Kids Goals, Sports; Doing Hard Things (01:31:21) Founders High School, Life Skills; Kids' Goals (01:42:44) Reimagining Classroom Education (01:47:21) Importance of Building & Creating, AI & Humanity (01:58:04) Science & Redesigning Experiments, Kids' Interest-Led Projects (02:05:26) Huberman Lab Live Events (02:06:14) Learning Predictors, Gender, Income; Redesigning the School System (02:18:32) Success; Sports Academy, Alpha School Expansion (02:28:36) Acknowledgements (02:31:07) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

In this Huberman Lab Essentials episode, my guest is Dr. Chris Palmer, MD, a board-certified psychiatrist and Assistant Professor of Psychiatry at Harvard Medical School. We explain how nutrition and metabolism directly affect mental health, including the biological mechanisms underlying these effects. We also discuss how carbohydrate restriction, ketogenic diets and fasting can improve mood, energy, and, in some cases, treatment-resistant psychiatric conditions. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman BetterHelp: https://betterhelp.com/huberman Timestamps (00:00:00) Chris Palmer (00:00:20) Personal Story, Nutrition & Mental Health (00:05:28) Treatment-Resistant Mental Disorders & Low-Carbohydrate Diet (00:07:32) Sponsor: Eight Sleep (00:08:51) Ketogenic Diet & Schizophrenia Success Story (00:12:20) Nutrition for Mental Disorders, Ketosis, Highly Processed Foods (00:15:13) Epilepsy & Ketogenic Diet, Fasting; Mitochondrial Benefits (00:21:14) Sponsor: BetterHelp (00:22:15) Mitochondria Functions, Mental Disorders (00:28:05) Mitophagy, Autophagy, Longevity & Calorie Restriction (00:33:12) Sponsor: AG1 (00:34:25) Carbohydrate Restriction, Depression Treatment (00:37:23) Acknowledgements Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices