Huberman Lab

In this Huberman Lab Essentials episode, my guest is Dr. Matthew MacDougall, a neurosurgeon at Neuralink. We discuss how brain-machine interfaces could help people with paralysis control computers using their intended movements, and how robotic surgery enables the placement of tiny electrodes in the brain. We also explore advances in brain tumor surgery, implant safety, how the brain and software learn to work together, and the role of animal research. Dr. MacDougall shares his vision for future applications, including restoring movement, addressing mental health conditions and expanding human cognition and communication. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman BetterHelp: https://betterhelp.com/huberman Rorra: https://rorra.com/huberman Timestamps (00:00:00) Matt MacDougall (00:00:23) Brain Function, Frontal Lobes & Impulse Control (00:02:57) Brain Tumors, Laser Surgery & MRI (00:04:38) Neuralink, Brain Implants & Paralysis (00:07:04) Robotic Surgery & Electrode Placement (00:08:02) Sponsor: BetterHelp (00:10:25) Motor Cortex, Controlling Computers With the Brain (00:12:20) Implant Safety & Brain Augmentation (00:14:07) RFID Hand Implant & Everyday Uses (00:16:25) Sponsor: AG1 (00:18:03) Spinal Cord Stimulation, Reconnecting Brain & Body (00:19:00) Brain-to-Brain Communication & AI (00:21:13) Brain-Machine Interfaces, Learning & Adaptation (00:23:43) Animal Research & Welfare (00:26:47) Pigs & Monkeys, Device Safety & Function (00:28:04) Sponsor: Rorra (00:30:32) Future Applications, Mental Health & Human Cognition (00:33:03) Acknowledgements Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Scott Kanoski, PhD, is a Professor of Human and Evolutionary Biology and Neurobiology at the University of Southern California. We discuss how different foods impact memory and cognitive function as well as cravings. We also discuss how GLP-1 drugs work to control hunger in the brain and body, the role of the gut microbiome, and the effects of artificial and low calorie sweeteners on hunger and satiety. This episode highlights how nutrition impacts much brain health and learning capacity and how our memory impacts food choices too. Read the full episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Function: https://functionhealth.com/huberman Helix Sleep: https://helixsleep.com/huberman LMNT: https://drinklmnt.com/huberman Our Place: https://fromourplace.com/huberman Timestamps (00:00:00) Scott Kanoski (00:02:33) GLP-1, Natural GLP-1 Production; GLP-1 Drugs, Microdosing (00:07:06) GLP-1 Drugs & Benefits (00:10:36) Sponsor: Our Place & Helix Sleep (00:13:24) GLP-1 & Hunger Suppression, Vagus Nerve; Food Noise (00:18:39) Artificial Sweeteners & Appetite, Preclinical Studies (00:26:50) Memory & Meals; Stress; Eating & Individualization, Fasting (00:33:42) Memory Impairments, Western Diet, High Sugar, Processed Food (00:42:33) Sponsor: AG1 (00:43:46) Dementia, Alzheimer’s Disease & Western Diet; Exercise (00:49:40) Vagus Nerve, Hippocampus & Memory, Hormones (00:57:10) Sugar & Fat Consumption, Memory; Engineering Food for Quality (01:04:32) GLP-1s, Nutrient Deficiency, Weight Loss & Other Effects (01:11:33) Sponsor: LMNT (01:12:54) Vagus Nerve & Hippocampus, Eating & Acetylcholine (01:21:05) Hippocampus, Memory & Food; Interoceptive Awareness & Western Diet (01:27:21) Omega-3s; Microbiome & Processed Foods (01:34:00) Microbiome, Antibiotics, C. diff Infection (01:37:23) Sponsor: Function (01:39:01) Foods to Enhance Microbiome; Rising Obesity & Highly Processed Food (01:43:39) Dopamine & Food Choice, Change Food Cravings (01:49:50) Food Addiction, Highly Processed Foods; Political Lobbying (01:56:43) Oxytocin, Reduced Food Consumption, Social Eating (02:00:11) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Social Media, Neural Network Newsletter Learn more about your ad choices. Visit megaphone.fm/adchoices

In this Huberman Lab Essentials episode, my guest is Dr. Elissa Epel, PhD, a Professor of Psychiatry and Behavioral Sciences at the University of California, San Francisco (UCSF). We discuss how acute and chronic stress affect the body and brain, including their links to cellular aging and mitochondrial health. We also explain tools to reduce rumination, reframe stress as a challenge and build resilience, as well as how radical acceptance and a sense of purpose can help us navigate stressors we cannot change. Read the full episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman ROKA: https://roka.com/huberman Timestamps (00:00:00) Elissa Epel (00:00:22) Good & Bad Stress, Stress Responses (00:01:55) Rumination, Body Awareness (00:03:23) Tools: Mindset, Body & Environment (00:04:51) Acute & Chronic Stress, Energy & Recovery (00:07:44) Sponsor: Eight Sleep (00:09:27) Healthy Aging, Purpose & Brain Health (00:10:54) Stress Resilience, Threat vs. Challenge (00:14:40) Tool: Reframe Stress, “Stress Shields” (00:16:54) Sponsor: AG1 (00:18:30) Mitochondrial Health, Caregiving & Daily Mood (00:21:24) Chronic Stress, Tool: Radical Acceptance (00:25:19) Tool: “Drop the Rope”, Uncontrollable Stressors (00:26:48) Uncertainty, Tool: Posture & Slow Breathing (00:29:10) Sponsor: ROKA (00:30:34) Taking Action vs. Letting Go (00:32:55) Journaling, Narrative & Purpose (00:34:15) Acknowledgements Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Beth Shapiro, PhD, is an evolutionary biologist and Chief Science Officer at Colossal Biosciences. Her work focuses on de-extinction and wildlife conservation efforts. We discuss genetic differences among humans, and how ancient DNA and modern embryology are being used to de-extinct and protect woolly mammoths, dodo birds, and dire wolves, as well as to help conserve endangered species. We also explore the ethical implications of de-extinction and how synthetic biology can help build a more bio diverse and resilient world. Read the full episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Joovv: https://joovv.com/huberman Eight Sleep: https://eightsleep.com/huberman Function: https://functionhealth.com/huberman Timestamps (00:00:00) Beth Shapiro (00:02:35) What is a Species?, Taxonomy, Bison (00:09:13) Neanderthals, Denisovans, Homo Sapiens (00:12:38) Sponsors: Joovv & Eight Sleep (00:15:27) Hybrid Ancestry, “Grolar” Bears (00:20:30) Homo Sapiens & Neanderthal Interbreeding, Genes; Denisovans (00:25:53) Neanderthal Genes, Immunity, Red Hair; Eye Color (00:30:17) De-Extinction, Species Selection, Woolly Mammoths (00:38:08) Sponsor: AG1 (00:39:21) Bird De-Extinction, Dodo; Reproduction & Genes (00:47:40) Development Biology, Woolly Mammoth, Elephants (00:54:49) Dire Wolf, Synthetic Biology, Ethics (01:03:26) De-Extinction, Ecology, Conservation, Ethics (01:09:22) Ecosystem Resilience, Thylacine; Preventing Extinction, Quolls (01:15:45) Sponsor: Function (01:17:23) Modeling Ecological Impact, Mosquitoes, Gene Drives; Panthers (01:25:50) Advisory Panels, Synthetic Biology Education (01:29:13) Genetic Selection in Humans, Human-Shaped World (01:38:25) Black-Footed Ferrets, Genetic Rescue (01:47:05) Dire Wolf; Ecological Modeling, New Technology & Public Fear (01:55:09) Artificial Wombs; Current Issues, Conservation & Red Wolf (02:01:26) Science Pioneers; Colossal Public Education (02:04:31) Beth’s Science Origin Story; Dinosaurs (02:13:42) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

In this Huberman Lab Essentials episode, I explain how the neurochemicals epinephrine, acetylcholine and dopamine contribute to focus and concentration. I discuss tools for improving attention, including sleep, sound, structured work sessions, nutrition, caffeine and deliberate cold exposure. I also describe a brief daily meditation and visual focus exercises that train your ability to refocus when attention drifts. Additionally, I discuss the potential benefits and limitations of supplements, prescription treatments for ADHD, and why taking time to deliberately defocus supports concentrated work. Read the full episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps (00:00:00) Focus & Concentration (00:02:00) Epinephrine, Acetylcholine & Dopamine (00:04:20) Sleep, White Noise & Pink Noise (00:07:35) Sponsor: LMNT (00:09:05) Ultradian Cycles, 90-Minute Work Sessions (00:10:45) Blood Glucose, Fasting & Meal Size (00:13:40) Caffeine, Focus & Sleep (00:15:00) Acute Stress & Concentration (00:16:55) Tool: Deliberate Cold Exposure (00:19:45) Sponsor: AG1 (00:21:00) Tool: 13-Minute Daily Meditation (00:25:10) Tool: Visual Focus Exercises (00:29:45) Sponsor: David (00:31:10) Omega-3 Fatty Acids & Creatine (00:33:00) Alpha-GPC, Acetylcholine & Safety Considerations (00:35:10) L-Tyrosine, Dopamine & Combining Tools (00:37:00) ADHD, Prescription Medications & Neuroplasticity (00:39:55) Deliberate Defocusing & Recovery (00:41:10) Acknowledgements Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices