Using Stem Cells to Cure Autism, Epilepsy & Schizophrenia | Dr. Sergiu Pașca
18 August - 2 hours 23 minsMy guest is Dr. Sergiu Pașca, MD, professor of psychiatry and behavioral sciences at Stanford University. We discuss the biology and genetics of autism, why autism diagnoses are increasing and recent progress in using stem cells to understand and treat profound autism and other brain disorders. Dr. Pașca explains “organoids and assembloids”—human stem cell–derived tools he pioneered to study, treat and cure complex brain diseases. We also discuss ethical and safety issues with using gene editing and stem cells in humans.
Read the episode show notes at hubermanlab.com.
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Defining Healthy Masculinity & How to Build It | Terry Real
Terry Real is a therapist and best-selling author expert on male emotional health and how men can build the skills for healthy relating to others: in relationships, work, friendships and to themselves. We discuss how mixed and ever-changing messages about what masculinity is are impacting the mental and physical health of men and boys. Terry explains how learning the skill of "relationality" leads to improvements in all aspects of boys' and men's lives and shares practical tools for how to do that. We also discuss the essential role of having a close male community to build confidence and self-esteem. This conversation offers actionable guidance for boys, men and women seeking to build healthier relationships with themselves and others. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman BetterHelp: https://betterhelp.com/huberman David: https://davidprotein.com/huberman Function: https://functionhealth.com/huberman Waking Up: https://wakingup.com/huberman Timestamps (00:00:00) Terry Real (00:02:53) Men & Masculinity, Political vs Psychological Patriarchy, Feminism (00:07:39) Stoicism, Vulnerability, Traditional Masculinity, Emotions (00:10:50) Sponsors: BetterHelp & David (00:13:14) Masculinity Across Decades, Giving; Gratification vs Relational Joy (00:21:54) Healthy Emotional Expression, Connection & Vulnerability; Self-Esteem (00:31:17) Feeling Emotions, Tools: Asking For Help; Fights & "What Do You Need?" (00:35:10) Self-Esteem & Relationship Accountability; Criticism, Redefining Strength (00:40:47) Sponsor: AG1 (00:42:32) Healthy Criticism, Tool: Women & Articulating Needs (00:50:21) Childlike Behavior, Wise Adult & Trauma, Tool: Relational Mindfulness (00:58:11) Tool: Responsible Distance Taking; Self-Interest; Relationship "Biosphere" (01:08:14) Alcohol, Men & Friends, Loneliness, Men's Retreat (01:17:51) Fraternities, Men's Groups, Tool: Relationship vs Individual Support (01:25:39) Sponsor: Function (01:27:27) Lack of Male Friends, Hiking, Community, Teaching Young Men (01:36:11) Cannabis, Alcohol, Young Men & Purpose, Flexibility & Manliness (01:40:40) Work, Life Purpose & Men; Skillful Warriors (01:45:01) Absent Fathers; Early Childhood & Proper Nurturing; Caretaking (01:53:24) Sponsor: Waking Up (01:54:47) Women & Speaking Relationally, Objectivity Battle (01:59:02) Addiction & Disconnection, 12-Step Meetings & Fellowship (02:08:04) Pornography, Internet, Intensity vs Intimacy; Optimization (02:11:57) Tool: Families & Hanging Out; Relational Joy; Relational Recovery (02:22:29) Giving Criticism, Tools: Make Requests; Feedback Wheel (02:28:21) Gratitude, Aging; Skillful Fighting in Relationship & Repair (02:34:17) Men & Self-Esteem, Mentors, Tool: Inner Dialogue without Harshness (02:44:00) Y Chromosome, Wholeness (02:48:00) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices
2 hours 50 mins
29 December Finished
Essentials: How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett
In this Huberman Lab Essentials episode, my guest is Dr. Kyle Gillett, MD, a dual board-certified physician in family medicine and obesity medicine and an expert in optimizing hormone levels to improve overall health. We explain how to improve hormone levels across the lifespan in both men and women using behavioral, nutritional and exercise-based tools. We also discuss common clinical topics, including hormone testing, PCOS, hair loss, testosterone replacement therapy (TRT) and peptides, focusing on potential benefits, tradeoffs and risks. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Maui Nui: https://mauinuivenison.com/huberman Function: https://functionhealth.com/huberman Timestamps (00:00:00) Kyle Gillett (00:00:36) Hormone Health; Women vs Men, Tool: Hormone Testing (00:02:35) Tool: Big 6 Lifestyle Pillars to Optimize Hormone Health (00:04:32) Sponsor: AG1 (00:06:17) Diet, Individualization; Bloodwork & Frequency (00:07:20) Exercise, Zone 2 Cardio; Caloric Restriction (00:08:36) Intermittent Fasting, Growth Hormone, IGF-1 (00:11:05) Hormones & Sleep, Growth Hormone, Menopause, Andropause, TRT (00:13:28) Testosterone & Women, SHGB (00:15:19) Sponsor: Maui Nui (00:16:34) Dihydrotestosterone (DHT), Androgens; Turmeric & Black Pepper; Hair Loss (00:19:47) Polycystic Ovarian Syndrome (PCOS), Symptoms, Metformin, Inositol (00:23:13) Cannabis, Alcohol, Testosterone (00:24:48) Males & Testosterone, TRT, Prostate Cancer (00:26:04) Prolactin, Dopamine "Wave Pool", Tool: Casein & Gluten (00:27:23) Sponsor: Function (00:29:03) Social Relationships & Hormones, Tool: Planning for Crisis (00:31:02) Peptides, Growth Hormone & Risk; BPC 157, Sourcing & LPS (00:36:42) Melanotan, Uses & Risks (00:38:45) Spiritual Health, Interdisciplinary Health Integration (00:41:23) Caffeine & Hormones, Sleep; Acknowledgements Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices
42 mins
25 December Finished
Transform Pain & Trauma Into Creative Expression | David Choe
explicitDavid Choe is a world-renowned artist, writer, podcaster and TV host. He tells how as a child, he was made to believe he was destined for greatness but also that he was a complete disgrace, leading him to channel his energy—including deep shame—into art that brought him global recognition. He shares about his addictions that put him on a decades-long cycle of extreme highs and lows and that forced him to eventually acknowledge and heal the childhood trauma he was battling inside. David shows up with raw, authentic presence to show us how we can transmute pain and shame into our best creative work and, more importantly, how complete vulnerability, especially about our hardest experiences, is the ultimate tool for forgiveness and self-acceptance. He also tells us the actual story about early Facebook, Pee-wee Herman and Santa Claus. Note: This conversation includes topics and language that may not be suitable for younger audiences. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman LMNT: https://drinklmnt.com/huberman Function: https://functionhealth.com/huberman Mateina: https://drinkmateina.com/huberman Timestamps 00:00:00 David Choe 00:03:10 Drawing, Black & Colors, Death 00:12:54 Telepathy, South Bay 00:17:52 Sponsors: Eight Sleep & LMNT 00:20:40 Childhood, Podcasts, Mundane Moments & Artist Life 00:28:45 Mother, Beliefs, Religion, Artistic Ability, Childhood 00:33:27 Gambling, Transformation; Immigrant, Disgrace 00:40:10 Street Art, Graffiti, Creativity; Paintings, Payment; Sports 00:52:08 Sponsor: AG1 00:53:30 Santa, Belief; Journal, Vulnerability; Heart Break, Art 01:00:16 Facebook, Graffiti; Theft, Gambling 01:10:57 Adapting, Creativity 01:17:16 Album Cover, Art & Payment 01:23:40 Sponsor: Function 01:25:28 Immigrant & Belonging, Academics, Learning Art, Marvel Comics, Shame 01:35:11 Shame, Gambling Addiction, Stress 01:43:05 Sexual Abuse, Trauma, Shame, Addiction 01:51:52 Early Career, Pornography, Author 02:01:20 Graffiti, Disappointment, Rejection; Early Magazines 02:08:26 Sponsor: Mateina 02:09:27 Pornography, Co-Dependence; Movie Set 02:18:00 Pride & Family, Vice; Pokémon 02:26:44 Podcast, Workaholism, Shame, Reality; Anthony Bourdain, Channing Tatum 02:38:54 Writing, Career Success, Workaholism, Vice, News, Self-Sabotage, Heart Attack 02:52:21 Growth & Pain, Sizzler; David Arquette 02:58:40 Rehab, God, Purpose, Parents & Disappointment, The Choe Show, Pee-Wee Herman 03:05:53 Gratitude, Korean Immigrant, Self-Reflection, Brokenness 03:14:37 Emotion, Saying No, Suicide; Vacation & Workaholism, Art 03:25:23 Legacy; Vacation, Work; Authenticity 03:31:15 Surviving & Thriving, Suicide, Addiction, Play the Tape Out, Fun, Feeling Enough 03:44:43 Hope & Faith, Electronics, Santa Claus 03:51:23 Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Learn more about your ad choices. Visit megaphone.fm/adchoices
3 hours 54 mins
22 December Finished
Essentials: How to Set & Achieve Goals
In this Huberman Lab Essentials episode, I explain how to use science-based tools to better set and achieve goals. I discuss the neuroscience of goal pursuit and how dopamine and visual attention shape motivation and effort. I explain whether visualizing success or failure better supports goal pursuit, how to choose goals at the right level of difficulty and evaluate progress. I also share a short “space-time bridging” protocol that helps train long-range, goal-directed behavior. These tools will help you stay motivated and reach goals more effectively. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps (00:00:00) Goal Setting (00:00:23) Brain & Goal Pursuit (00:03:32) Goal Value, Action Steps (00:05:49) Sponsor: David (00:07:07) Peripersonal vs Extrapersonal Space (00:08:34) Tool: Visual Focus & Pursuing Goals (00:13:04) Visualization & Goal Pursuit, Tool: Visualize Failure (00:15:25) Sponsor: AG1 (00:16:48) Tool: Goal Setting & Difficulty Level (00:18:27) Dopamine & Goal Pursuit, Reward Prediction Error, Tool: Weekly Goal Assessment (00:23:39) Dopamine & Vision; Importance of Behavioral Tools (00:25:37) Recap of Tools for Goal Setting & Pursuit (00:26:49) Sponsor: LMNT (00:28:21) Goal Pursuit, Time; Tool: Space-Time Bridging (00:35:49) Recap, Key Takeaways Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices
37 mins
18 December Finished
Improve Energy & Longevity by Optimizing Mitochondria | Dr. Martin Picard
Dr. Martin Picard, PhD, is a professor of behavioral medicine at Columbia University and an expert on how our behaviors and psychology shape cellular energy production and rates of aging. He explains that your mitochondria don’t just “make energy”; they translate what you do—your mindset and your relationships—into the energy you experience as vitality or lack thereof. He explains how exercise, nutrition, sleep, meditation, and even certain thought patterns and our sense of purpose can charge our cells like batteries. He also shares findings that hair greying is the result of cellular stress and is reversible. This episode links physical and mental ‘energy’ with cellular energy and provides science-supported tools to improve your physical and mental health. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Helix: https://helixsleep.com/huberman Lingo: https://hellolingo.com/huberman Function: https://functionhealth.com/huberman Waking Up: https://wakingup.com/huberman Timestamps (00:00:00) Martin Picard (00:03:50) What is Energy?, Energy Flow & Transformation (00:07:53) Energy, Vitality, Emotions, Sensory Perception (00:14:18) Sponsors: Helix Sleep & Lingo (00:17:19) “Mito-Centric” View of World, Mitochondrial Energy & Information Patterns (00:25:26) Organelles, Mitochondria & Energy Transformation; Maternal Genes (00:31:12) Mitotypes & Differentiation, Mitochondria as “Social Organisms” (00:36:52) Food & Dysfunctional Energy Transformation (00:40:02) Lifestyle Choices & Interests, Physiological Growth (00:46:39) Pregnancy, Amenorrhea; Illness & Tiredness (00:51:07) Sponsor: AG1 (00:52:29) Energy Transformation & Distribution; Body’s Wisdom, Feeling Sick (00:56:27) Tool: Feel Your Energy; Breath & Energy (01:02:31) Flow of Energy; Trade-Offs, Life Purpose & Enjoyment (01:10:15) Biology, Meaningful Experiences & Energy Flow (01:16:27) Sponsor: Function (00:18:15) Inflammation, Energetic Flow (01:20:43) Child Prodigies, Species Lifespan & Mitochondrial Metabolism; Aging (01:28:56) Lifestyle & Aging: Exercise, Fasting; Inflammation, Sleep, Stimulants (01:37:06) Energetic Stress Signals, GDF-15, Cancer, Heart Failure (01:42:18) Genes, Lifestyle & Aging (01:47:54) Gray Hair Reversal, Stress; Inflammation & Aging (01:57:37) Energy Recovery, Sleep & Mitochondrial Function, Stress, Meditation (02:05:16) Tools: Yoga Nidra, NSDR; Pre-Sleep Relaxation, Energy & Restorative Sleep (02:10:58) Diet & Individualization, Clinical Trials; Mitochondria & Nutrition, Keto (02:20:14) Alcohol & Energy Budget; Stress (02:25:02) Exercise, Increase Mitochondria, Overtraining; Resistance & Growth (02:33:06) Sponsor: Waking Up (02:34:41) Supplements & Mitochondria Health, Deficiencies, SS31, Methylene Blue (02:41:31) Energy Flow & Experiences, Balance (02:49:13) Transform Through Resistance, Energetic Awareness, Connection (02:56:05) Food Overconsumption & Mitochondria Disruption; Tissues & Mitochondria (03:01:02) Mitochondrial Health Test; Tool: Ways to Increase Energy; Meditation (03:06:10) Peptides; Fertility Supplements, Urolithin A; Electromagnetic Fields (03:12:16) Acknowledgements (03:14:15) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Learn more about your ad choices. Visit megaphone.fm/adchoices
3 hours 17 mins
15 December Finished
Essentials: How to Build, Maintain & Repair Gut Health | Dr. Justin Sonnenburg
In this Huberman Lab Essentials episode, my guest is Dr. Justin Sonnenburg, PhD, a professor of microbiology and immunology at Stanford University. We discuss how microbes in our gut impact our mental and physical health and how diet and the environment affect the gut microbiome. We explain how lifestyle factors such as antibiotics and Western-style diets (high fat, low fiber and rich in processed foods) can damage gut diversity and whether prebiotics or probiotics are useful tools. Throughout the episode, we highlight evidence-based dietary and lifestyle strategies for improving gut health. Episode show notes: https://go.hubermanlab.com/VXfckJf Thank you to our sponsors AG1: https://drinkag1.com/huberman Joovv: https://joovv.com/huberman Function: https://functionhealth.com/huberman Timestamps 00:00:00 Justin Sonnenburg 00:00:20 What is the Microbiome? 00:02:55 Microbiome Origin, Babies, Environmental Factors 00:04:47 Healthy Microbiome, Individuality; Industrialized vs Traditional Populations 00:07:06 Sponsor: AG1 00:08:30 “Reprogramming” the Gut Microbiome; Antibiotics, Western Diet 00:12:58 Cleanses & Fasting 00:13:55 Processed Foods & Microbiome, Artificial Sweeteners, Emulsifiers 00:17:35 Sponsor: Joovv 00:18:55 Inflammatory Western Diseases, Microbiome & Immune System 00:21:51 Fiber, Fermented Foods & Microbiome, Tool: Fermented Food Consumption 00:28:20 Sponsor: Function 00:30:00 Fiber, Depleted Microbiome, Industrialization, Sanitation 00:31:33 Antibiotics, Over-Sanitation, Disease, Hand Washing 00:33:26 Probiotics, Tool: Product Validation, 00:35:15 Prebiotics, Tool: Plant Consumption 00:37:48 Good Gut Book, Justin’s Research Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices
39 mins
11 December Finished