Rebuilding America's Industrial Backbone

Jack Altman joins Speedrun to discuss product-market fit, customer feedback, hiring, fundraising, and the realities of building an enduring company. Drawing on his experience building Lattice from startup to multi-billion-dollar company, Altman explains how founders should think about customer requests, when to pivot, and why some of the hardest decisions come from balancing conviction with market feedback. He shares lessons from the early days of Lattice, including finding product-market fit, building a sales motion, hiring the first employees, and navigating the tradeoffs that emerge as companies scale. The conversation also covers fundraising, co-founder relationships, startup momentum, and what Altman looks for today as an investor at Alt Capital.

Yoko Li and Justine Moore speak with Ideogram founder and CEO Mohammad Norouzi about image generation models, design workflows, and the evolving relationship between AI and creative work. The conversation covers Ideogram's decision to release an open-weight model, the challenges of generating text and layouts within images, and why controllability has become an increasingly important area of research. They discuss prompting, customization, editing, and the tradeoffs between general-purpose models and systems optimized for specific creative tasks. Along the way, Norouzi shares his views on open-source AI, design tools, agentic workflows, and how image generation models may evolve as creators and enterprises seek greater control over their outputs.

Theo Jaffee speaks with Samo Burja, founder of Bismarck Analysis, about AI, industrial capacity, economic growth, and the institutions that shape civilization. The conversation explores how AI’s demand for compute, energy, and infrastructure could trigger a new wave of industrial expansion, benefiting sectors far beyond technology. Burja argues that AI is not just a software story but a demand shock that will ripple through energy, manufacturing, construction, and global supply chains. They also discuss China and the United States, demographic decline, fertility, state capacity, welfare systems, and the political economy of automation. Along the way, Burja shares his views on functional institutions, economic growth, and why societies that can effectively organize people and resources may have an enduring advantage in the AI era.

Erin Price-Wright speaks with Alex Modon, cofounder and CEO at Unlimited Industries, and Davide Asnaghi, CEO at Diode Computers, about how AI is moving from software into the physical world. They discuss automating construction and electronics design, using code and simulation to model real-world systems, and how incentives and manufacturing constraints shape adoption. They also examine what it takes to scale infrastructure, reduce build times, and unlock more abundant industrial capacity in the United States.

SCAN Health Plan CEO Sachin Jain speaks with a16z General Partner Anish Acharya about AI, healthcare, and what it takes for established organizations to adapt during periods of technological change. The conversation explores how AI is reshaping work, customer experience, software development, and organizational structure. Acharya argues that artificial intelligence is not simply another productivity tool, but a fundamentally new technology capable of performing work on behalf of people and organizations. They discuss AI adoption inside large enterprises, the future of customer support, software development, healthcare operations, and why curiosity, experimentation, and ambition may be the most important traits for organizations navigating the transition. Along the way, Acharya shares his views on economic growth, human flourishing, and the role AI could play in reducing healthcare costs and improving patient experiences.