The a16z Show

This conversation with Alex Karp, cofounder and CEO of Palantir, was recorded at the a16z American Dynamism Summit in Washington, D.C. Karp discusses the role of technology in modern warfare, Silicon Valley's obligations to national defense, and why he believes America's single greatest competitive advantage is its ability to cultivate and protect unconventional talent.

In this episode, previously aired on Cheeky Pint, Garrett Langley describes how a stolen gun in his Atlanta neighborhood led him to build Flock Safety, now deployed in more than 6,000 cities and involved in clearing over a million crimes last year. He covers how the product has evolved from license plate cameras to drones, real-time 911 integration, and an AI-powered orchestration layer for city safety.

Anish Acharya speaks with Olivia Moore about the latest edition of the a16z Top 100 AI Apps report. They cover why ChatGPT is still 30 times bigger than Claude on web, how the three major platforms are specializing for different users, what global adoption data reveals about cultural attitudes toward AI, and why agents, memory, and voice are about to change everything.

Daisy Wolf speaks with Dr. Andrew Huberman, professor of neurobiology and ophthalmology at Stanford University and host of the Huberman Lab podcast. They discuss how the pandemic sparked a consumer health revolution, the emerging peptide and GLP landscape, what the science actually says about focus drugs, and the neurotechnologies Huberman believes will let us write to our own biology within the next five years.

Alex Rampell and Erik Torenberg speak with Mike Cannon-Brookes, cofounder and CEO of Atlassian, about how to make sense of the SaaS selloff, why not all software companies face the same AI-driven risks, and how Atlassian is thinking about the shift from records to processes. They also examine the real design challenge of getting everyday users to trust and benefit from AI agents in enterprise workflows.