
Grand Challenges in Healthcare AI
7 September 2024 - 37 minsVijay Pande, founding general partner, and Julie Yoo, general partner at a16z Bio + Health, come together to discuss the grand challenges facing healthcare AI today.
The talk through the implications of AI integration in healthcare workflows, AI as a potential catalyst for value-based care, and the opportunity for innovation in clinical trials. They also talk about the AI startup they each wish would walk through the door.
Resources:
Find Vijay on Twitter: https://x.com/vijaypande
FInd Julie on Twitter: https://x.com/julesyoo
Listen to more episode from Raising Health: https://a16z.com/podcasts/raising-health/
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Stablecoins & the Future Financial System
a16z Crypto General Partners Ali Yahya, Arianna Simpson, and Erik Torenberg break down what’s actually working in crypto today - starting with the rise of stablecoins as a real-world payments layer. They discuss how stablecoins are being adopted by companies like Stripe and SpaceX, why regulatory shifts are opening new doors for crypto startups, and how AI and crypto are beginning to intersect. They also cover: - The future of decentralized social networks - Where Ethereum, Solana, and others stand today - Misconceptions still holding the space back A grounded conversation on what’s real, what’s hype, and where crypto’s finally finding traction.
37 mins
9 July Finished

How Andreessen Horowitz Disrupted VC & What’s Coming Next
On this episode, taken from The Ben & Marc Show, a16z co-founders Marc Andreessen and Ben Horowitz dive deep into the unfiltered story behind the founding of Andreessen Horowitz—and how they set out to reinvent venture capital itself. For the first time, Marc and Ben walk through the origins, strategy, and philosophy behind building a world-class venture capital firm designed for the future—not just the next fund. They reveal how they broke industry norms with a bold brand, a full-stack support model, and a long-term commitment to backing exceptional builders—anchored in the radical idea that founders deserved real support, not just checks. Joining them to guide the conversation is Erik Torenberg—Andreessen Horowitz’s newest General Partner—who makes his Ben & Marc Show moderating debut. Erik is a technology entrepreneur, investor, and founder of the media company Turpentine.
1 hour 23 mins
7 July Finished

Enabling Agents and Battling Bots on an AI-Centric Web
Taken from the AI + a16z podcast, Arcjet CEO David Mytton sits down with a16z partner Joel de la Garza to discuss the increasing complexity of managing who can access websites, and other web apps, and what they can do there. A primary challenge is determining whether automated traffic is coming from bad actors and troublesome bots, or perhaps AI agents trying to buy a product on behalf of a real customer.Joel and David dive into the challenge of analyzing every request without adding latency, and how faster inference at the edge opens up new possibilities for fraud prevention, content filtering, and even ad tech.Topics include: -Why traditional threat analysis won’t work for the AI-powered web -The need for full-context security checks -How to perform sub-second, cost-effective inference -The wide range of potential actors and actions behind any given visit As David puts it, lower inference costs are key to letting apps act on the full context window — everything you know about the user, the session, and your application.
26 mins
4 July Finished

Marc Andreessen on Startup Timing
What if now is the best time in decades to start a company? In this episode, taken from Speedrun, a16z’s accelerator for early-stage founders, Marc Andreessen joins games General Partner Jonathan Lai to make the case that we’re entering a once-in-a-generation window for innovation. From the rise of AI to the cultural and policy shifts reshaping the global economy, Marc explains why the next four years present a rare opportunity for builders to seize the moment. Along the way, they discuss market timing, platform shifts, and what sets successful founders apart - including lessons from Steve Jobs, insights into AI’s impact on storytelling and games, and why being “too early” can feel just like being wrong.
18 mins
2 July Finished

Katherine Boyle: How Tech Can Rebuild America
Why does seriousness feel radical today? a16z General Partner Katherine Boyle joins The LaBossiere Podcast to explore what it means to build for the national interest—and why that starts with purpose. Katherine, part of the American Dynamism team at a16z, shares how we got to a place where public service became uncool, how tech can help rebuild trust in government, and why suffering, friction, and responsibility are essential ingredients for growth. From the collapse of civic duty to the rise of meme-driven politics, they dig into the cultural forces shaping America—and the opportunity to reclaim a sense of mission. They also discuss why Silicon Valley is more idea than place, what journalists and investors have in common, and why being laughed at might be the clearest sign you’re on the right path.
52 mins
30 June Finished

Where We Are in the AI Cycle
In this episode of ‘This Week in Consumer’, a16z General Partners Anish Acharya and Erik Torenberg are joined by Steven Sinofsky - Board Partner at a16z and former President of Microsoft’s Windows division - for a deep dive on how today’s AI moment mirrors (and diverges from) past computing transitions. They explore whether we’re at the “Windows 3.1” stage of AI or still in the earliest innings, why consumer adoption is outpacing developer readiness, and how frameworks like partial autonomy, jagged intelligence, and “vibe coding” are shaping what gets built next. They also dig into where the real bottlenecks lie, not in the tech, but in how companies, products, and people work.
30 mins
27 June Finished